Automotive Fleet
MenuMENU
SearchSEARCH

50% of Drivers Use Potentially Impairing RX or OTC Meds

The potential effects of medication while behind the wheel can lead to deadly consequences, yet research finds that healthcare professionals fail to warn up to half of drivers.

July 29, 2022
50% of Drivers Use Potentially Impairing RX or OTC Meds

People who receive a warning from a healthcare professional are 18% less likely to get behind the wheel after taking medication.

2 min to read


Approximately 50% of drivers said they used one or more potentially impairing medications in the past 30 days, according to new research from the AAA Foundation for Traffic Safety. Moreover, the proportion of those choosing to drive is higher among those taking multiple medications — a worrisome fact.

Drug use and driving don't mix — even if it’s a prescription medication. A 2020 study of multiple trauma centers found that 56% of drivers involved in serious injury and fatal crashes tested positive for at least one drug, according to the National Highway Traffic Safety Administration (NHTSA).

Ad Loading...

And, a 2020 traffic safety study from AAA Foundation found that most drivers — some 94% — consider driving after drinking alcohol very or extremely dangerous. But, only 87% feel the same about driving after using potentially impairing medications.

Now, the latest study from AAA Foundation explores drivers’ use of prescription and over-the-counter (OTC) medicines and confirms that motorists lack an understanding of their impact on driving, and healthcare professionals are not helping the problem.

For example, healthcare providers failed to warn many respondents who took prescriptions and over-the-counter medications such as antihistamines, cough medicines, antidepressants, prescription pain medicines, muscle relaxants, sleep aids, and amphetamines about their possible dangerous impact on driving. 

In fact, up to half of drivers who were prescribed and took each type of potentially driver impairing (PDI) medication did not report receiving a warning from their medical provider or pharmacist regarding its possible impacts on driving.

Yet the potential effects can be hazardous when mixed with driving. People may experience dizziness, sleepiness, fainting, blurred vision, slowed movement, and attention problems — all of which can lead to deadly consequences if they occur while behind the wheel.

Ad Loading...

On the upside, those survey respondents who did receive a warning from a healthcare professional were 18% less likely to get behind the wheel after medication use — highlighting the potential benefit of healthcare providers’ counseling to reduce medication-impaired driving.

The AAA Foundation study also examined which types of drugs people were taking and most apt to use before hitting the road. Antihistamines and cough medicines — many available without a prescription — were most commonly used. However, the proportion of drivers that reported driving after use was highest for those who reported amphetamine use, such as Adderall and Dexedrine.

More Safety

Chris Brown sits across from safety experft at Lifesaver mobile in an interview about distracted driving and phone use tech.
Safetyby Chris BrownMay 1, 2026

Reducing Risk by Eliminating Phone Use Behind the Wheel

Distracted driving remains one of the most persistent risks in fleet operations. New approaches focus on removing mobile device use entirely while adding real-time safety support.

Read More →
Safetyby Jeanny RoaApril 15, 2026

Distracted Driving in the Age of Smart Tech – Part 2

As distraction risks evolve, fleets are turning to smarter, more connected technologies to better understand what’s happening behind the wheel. Part 2 explores how these tools are helping identify risky behaviors and improve visibility across operations.

Read More →
Safetyby Jeanny RoaApril 11, 2026

 Data Rights, Risks, and Responsibilities After a Crash

What fleets capture to improve safety can also expose them in litigation, forcing leaders to rethink how data is managed, stored, and shared.

Read More →
Ad Loading...
Driver holding a phone while steering, illustrating distracted driving and the importance of mental awareness and attention on the road for fleet safety.
Safetyby Judie NuskeyApril 10, 2026

From Distraction to Detection: Strengthening Awareness in Fleet Drivers

Distracted driving is often measured by what we can see—phones in hand, eyes off the road. But what about the distractions we can’t? A recent incident raises a bigger question about awareness, attention, and why subtle risks so often go unnoticed.

Read More →
Safetyby StaffApril 8, 2026

Lytx 2026 Road Safety Report

While serious crashes are declining, a rise in minor incidents and ongoing risk hotspots underscore the need for continued fleet safety investment.

Read More →
Driver’s hands on steering wheel in a sunlit vehicle, representing real-world driver behavior and the shift from data monitoring to hands-on training in fleet safety programs.
Safetyby Judie NuskeyApril 7, 2026

Behind-the-Wheel vs. Classroom Training: What Actually Changes Driver Behavior?

Fleets have more driver data than ever, so why isn't behavior changing? Training requires more than reports and coaching — it requires real-world practice.

Read More →
Ad Loading...
A person in a car on their phone behind the steering wheel.
Safetyby Jeanny RoaApril 1, 2026

Distracted Driving in the Age of Smart Tech – Part 1

A two-part conversation with Stefan Heck on how AI is transforming the fight against distracted driving. As fleets adopt smarter tools, the focus shifts from reacting to preventing risk. In Part 1, we look at where AI is making an impact for fleets today.

Read More →
Pedestrians crossing a busy street, highlighting the importance of driver awareness and caution to prevent pedestrian accidents.
Safetyby StaffMarch 30, 2026

Pedestrian Safety Starts With the Driver

More people on foot means more risk for drivers. These pedestrian safety tips can help prevent serious injuries and keep everyone safer on the road.

Read More →
SponsoredMarch 30, 2026

Safety by Design: Power and Protection in the Freightliner 114SD Plus

Safer crews. Fewer incidents. Better uptime. Learn how driver-assist technology is changing the way vocational fleets operate.

Read More →
Ad Loading...
Safetyby StaffMarch 26, 2026

Pedestrian Deaths Drop in First Half of 2025, Marking Largest Decline in Years

An 11% drop in pedestrian fatalities in early 2025 signals progress in U.S. road safety, but elevated death rates and ongoing risks underscore the need for continued action from fleets and policymakers.

Read More →